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KMID : 0895820040140010129
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Journal of Oriental Rehabilitation Medicine
2004 Volume.14 No. 1 p.129 ~ p.142
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Comparative Studies of K orean Red Ginseng and American Ginseng on Protective Effects against Environmental Hormones-induced Toxicity and Their Chemical Compositions
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Choi Seung-Hoon
Wee Jae-Joon
Oh Min-Seok
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Abstract
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Objective: This study was carried out to reveal differences between Korean red ginseng(Panax ginseng C.A. Meyer) and American ginseng(Panax quinquefolius L.) on the protective effects against environmental hormones-induced toxicity.
Methods: For the assessment of experiment, male Sprague Dawley rats were divided to normal control, TCDD only and TCDD plus saponins (40mg/kg)-administered groups. A single dose of TCDD (50㎍/kg) was intraperitoneally injected to rats on the seventh day.
Results: Administrations of Korean red ginseng saponin fraction reduced TCDD-induced weight loss and histopathological lesions of liver and testis. In contrast, administration of American ginseng did not. A percentile of ginsenoside Rh1 was peculiarly high in Korean red ginseng and administration of ginsenoside Rh1 (20mg/kg) attenuated the TCDD-induced weight loss and histopathological lesions of liver and testis were also reduced.
Conclusions: The saponin of Korean red ginseng might prevent the endocrine disruptor-induced toxicity whereas American ginseng did not. It is also not able that the difference of pharmacologocal activity between Korean red ginseng and American ginseng may be originated from their different chemical compositions.
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KEYWORD
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Korean red ginseng, American ginseng, TCDD, ginsenoside Rh1
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